Prostate cancer surgery, Removing a prostate 'can double cancer survival rate'
DOI: Myc-associated zinc-finger prostate cancer surgery MAZ is a well-documented oncogene involved in the progression and metastasis of multiple cancer types, even in PCa.
However, the clinical significance and biological roles of MAZ in bone metastasis of PCa remain unclear. Statistical analysis was performed to evaluate the clinical correlation between MAZ expression and clinicopathological features and bone metastasis-free survival in PCa patients.
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Biological roles of MAZ in bone metastasis of PCa were investigated both in vitro by transwell assay, and in vivo by a mouse model of left cardiac ventricle inoculation.
The bioinformatics analysis, western blot, pull-down assays, chromatin immunoprecipitation ChIP and luciferase reporter assays were applied to demonstrate and examine the relationship between MAZ and its potential downstream signalling pathway.
TaqMan copy number assay was performed to identify the underlying mechanism responsible for MAZ overexpression in PCa tissues. Results: MAZ expression is elevated in PCa tissues with bone metastasis compared with that in PCa tissues without bone metastasis, and is further increased in metastatic bone tissues.
High expression of MAZ positively correlates with poor overall and bone metastasis-free survival in PCa patients. Upregulating MAZ elevates, while silencing MAZ represses the invasion and migration abilities of PCa cells in vitro and bone metastasis ability in vivo.
Finally, our results indicate that recurrent gains contribute to MAZ overexpression in a small portion of PCa tissues. MeSH terms.